Khan MF, Husain FM, Zia Q, Ahmad E, Jamal A, Alaidarous M, Banawas S, Alam MM, Alshehri BA, Jameel M, Alam P, Ahamed MI, Ansari AH, Ahmad I. ACS Omega. In this study, we investigated the effect of various concentrations of zinc oxide (ZnO) NPs (0, 1, 5, 20, 100, and 1000 mg kg −1 of soil) on lettuce (Lactuca sativa L.) and carrot (Daucus carota subsp. 2012 May 2;12:60. doi: 10.1186/1472-6882-12-60. Anti-quorum Sensing and Anti-biofilm Activity of Zinc Oxide Nanospikes.  |  Zinc oxide nanoparticles (ZnO-NPs) are increasingly used in sunscreens, biosensors, food additives, pigments, rubber manufacture, and electronic materials. 30 nm) showed that small particles in aquatic systems and their bioavailability does not have to be significantly greater than that of larger particles. Keywords: A combined toxicity study of zinc oxide nanoparticles and vitamin C in food additives. compared the toxicity of various metal oxide nanoparticles and zinc chloride to a Freshwater Microalga. This paper reviews the methods of synthesizing zinc oxide nanocomposites as well as their characteristics, antimicrobial activity and cytotoxicity against normal and tumor cells. Please enable it to take advantage of the complete set of features! HHS COVID-19 is an emerging, rapidly evolving situation. Results: Silver and zinc oxide nanoparticles (Ag and ZnO NPs) are widely used as antimicrobial agents.  |  It is now widely recognized that dissolution plays an important role in metallic nanoparticle toxicity, but to what extent remains unclear. There is a single study of repeated skin exposure in rats (ten per cent of body area treated for five days a week, over four weeks). The study used nanoparticulate ZnO (ca. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. The nanoparticles (NPs) have been increasingly manufactured in industry because of the well-known characteristics such as high reactivity, electromagnetic properties and high antibacterial property [].Zinc oxide nanoparticle (nZnO), one of the most popular manufactured metal oxide nanomaterials, has unique properties (i.e., surface area and reactive sites) due to the extremely small … 2014 Nov;33(11):1150-7. doi: 10.1177/0960327113510327. Epub 2016 Jun 7. COVID-19 is an emerging, rapidly evolving situation. After standard phases of preparation, injections were done intraperitoneally in chronic groups with zinc oxide nanoparticles (20 and 40 mg/kg) every other day and for acute groups with 200 and 400 mg/kg in a single dose. Environmental Science and Pollution Research 2019 , 26 (3) , … Whether zinc nanoparticles (NPs) are phytotoxic or beneficial to plants remains controversial because of limited research. Clipboard, Search History, and several other advanced features are temporarily unavailable. HHS Epub 2015 May 18. Epub 2016 Feb 9. This study investigates the toxic effects of ZnO-NPs in human lung cells. Clipboard, Search History, and several other advanced features are temporarily unavailable. Zinc oxide nanoparticles are nanoparticles of zinc oxide (ZnO) that have diameters less than 100 nanometers. Furthermore, zinc oxide nanoparticles induced cytotoxicity in human lung epithelial cells via inducing oxidative stress in a concentration-dependent manner, resulting in DNA damage and apoptosis [36 Sahu D, Kannan GM, Vijayaraghavan R, Anand T, Khanum F. Nanosized zinc oxide induces toxicity in human lung cells. This kind of nanomaterial shows serious adverse effects on human respiratory system as it can pass through alveolar epithelial cells into lung … Abbasalipourkabir R, Moradi H, Zarei S, Asadi S, Salehzadeh A, Ghafourikhosroshahi A, Mortazavi M, Ziamajidi N. Food Chem Toxicol. Epub 2018 Mar 15. Effect of annealing temperature on antimicrobial and structural properties of bio-synthesized zinc oxide nanoparticles using flower extract of Anchusa italica. High luminescent efficiency, a wide band gap (3.36eV), and a large exciton binding energy (60meV) has triggered intense research on the production of nanoparticles using different synthesis methods and on their future applications. Please enable it to take advantage of the complete set of features! 2020 Sep 30;8:778. doi: 10.3389/fchem.2020.00778. ; nano-zinc oxide; oxidative stress. Material and methods: Nowadays, a lot of studies were carried out about side effects of nanoparticles especially nano-zinc oxide, but unfortunately, most of these studies have been conducted with high doses. 10.1166/jnn.2010.2483. Zinc oxide (ZnO) has long been recognized as an effective sunscreen agent. Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes. Toxicity is a combined effect of zinc oxide nanoparticles and Zn 2+ ions released in the aqueous medium. Mohd Yusof H, Abdul Rahman N, Mohamad R, Zaidan UH, Samsudin AA. Zinc oxide nanocomposites show also selective toxicity toward normal and cancerous cells, which is explained by reactive oxygen formation (ROS). 2014;6(24):15333–15342. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. NIH Happy Agarwal, Soumya Menon, Venkat Kumar S, Rajeshkumar S. Chem Biol Interact. DOI: 10.1007/s40820-015-0040-x Corpus ID: 3669662. Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism @article{Sirelkhatim2015ReviewOZ, title={Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism}, author={Amna Sirelkhatim and S. Mahmud and A. Seeni and Noor Haida Mohamad Kaus and Ling Chuo Ann and S. K. M. Bakhori and … sativus) plants. In the present study, it was found that ZnO‐engineered nanoparticle (ZnO‐EN) toxicity to the marine diatom Thalassiosira pseudonana could be solely explained by … J Photochem Photobiol B. Introduction: Xia T, Kovochich M, Liong M, et al. 2015;25(4):334-9. doi: 10.3109/15376516.2015.1045654.  |  Zinc oxide nanoparticles have also been tested for longer-term toxicity in animals, using both skin tests and experiments in which suspended particles are inhaled. Biosynthesis of zinc oxide nanoparticles using. ZnO induced toxicity in both cells, leading to the generation of reactive oxygen species (ROS), oxidant injury, excitation of inflammation, and cell death. 2016 Aug;161:441-9. doi: 10.1016/j.jphotobiol.2016.06.007. Fouda A, El-Din Hassan S, Salem SS, Shaheen TI. However, their potential toxicological impact on environmental microorganisms is largely unexplored. Zinc Oxide (ZnO) is one of the most exploitable nanoparticles (NPs) in industrial and consumer products especially in cosmetics, food additives, pharmaceuticals, biosensors, photo electricity and rubber industry etc. Zinc oxide nanoparticles induced cyto- and genotoxicity in kidney epithelial cells. Keywords: It indicates an important role of Zn 2 + ions in the cytotoxicity of zinc oxide nanoparticles. A severe to slight damage was observed in liver tissue … Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. PMID: 30489211 [Indexed for MEDLINE] Publication Types: Review; MeSH terms. Zinc oxide nanoparticles (ZnO NPs) are being utilized in an increasing number of fields and commercial applications. After the determined time for every group (21 days for chronic groups and 7 days for acute groups), blood samples were provided from rat hearts and also liver, kidney and testicular tissue were removed for histological studies. 43). There were significant decreases in lymphocytes and platelet counts and significant increases in white blood cells count, hemoglobin and hematocrit in acute dose compared to control group and no difference in red blood cells count in all groups. This site needs JavaScript to work properly. They exhibit antibacterial, anti-corrosive, antifungal and UV filtering properties. ZnO nanopowders are available as powders and dispersions. neuronal or epithelial cells). Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. ZnO nanomaterials can be used in industry as nano-optical and nano-electrical devices, in food packaging and in medicine as antimicrobial and antitumor agents. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. This article provides further detail on the properties and applications of zinc oxide nanoparticles (ZnO). Zinc oxide nanocomposites show also selective toxicity toward normal and cancerous cells, which is explained by reactive oxygen formation (ROS). Epub 2015 Aug 24. CAS Article PubMed Google Scholar NLM eCollection 2020. This site needs JavaScript to work properly. Recently, various approaches including physical, chemical and biological ("green chemistry") have been used to prepare ZnO nanocomposites with different morphologies. Toxic effect of nano-zinc oxide There were significant decreases in lymphocytes and platelet counts and significant increases in white blood cells count, hemoglobin and hematocrit in acute dose compared to control group and no difference in red blood cells count in all groups. Zinc oxide NPs can be synthesized by a number of physical, chemical and biological methods. Accute Toxicity Satureja ZnO Nanoparticles Bioassay Test LC 50 96h Abstract Nanoparticles are commonly synthesized chemically and because of their risk for living was carried out to evaluate the acute toxicity of zinc oxide nanoparticles synthesized from Satureja hortensis on rainbow trout (Oncorhynchus mykiss) by static bioassay test. The impact of morphology and size of zinc oxide nanoparticles on its toxicity to the freshwater microalga, Raphidocelis subcapitata. Corrigendum to "Zinc oxide nanoparticles: synthesis, antiseptic activity and toxicity mechanism" Adv Colloid Interface Sci 249 (2017) 37-52. Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism View 0 peer reviews of Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism on Publons COVID-19 : add an open review or score for a COVID-19 paper now to ensure the latest research gets the extra scrutiny it needs. Copyright © 2017 Elsevier B.V. All rights reserved. Using ICP-MS and fluorescent-labeled ZnO, it is found that ZnO dissolution could happen in culture medium and endosomes. 2018 Dec 20;14:87-100. doi: 10.2147/IJN.S186888. Amara S, Slama IB, Mrad I, Rihane N, Khemissi W, El Mir L, Rhouma KB, Abdelmelek H, Sakly M. Hum Exp Toxicol. Zinc oxide nanoparticles (ZnO-NPs) have been reported as an antimicrobial agent against both pathogenic and spoilage microorganisms ... L. C., Bakhori, S. K. M., Mohamad, D., Review on zinc oxide nanoparticles: Antibacterial activity and toxicity mechanism. Zinc oxide (ZnO), as a material with attractive properties, has attracted great interest worldwide, particularly owing to the implementation of the synthesis of nano-sized particles. USA.gov. 2020 Dec 10;5(50):32203-32215. doi: 10.1021/acsomega.0c03634. Appl Microbiol Biotechnol. The ZnO nanomaterials release into the aquatic ecosystems through domestic and industrial wastewaters has the potential to induce pernicious effects on fish and other organisms. The current hazard assessment of the emerging chemical contaminant, zinc oxide nanoparticles (ZnO-NPs), seldom considers the influence of environmental factors. Epub 2018 Sep 18. Biosynthesis of zinc oxide nanoparticles by cell-biomass and supernatant of Lactobacillus plantarum TA4 and its antibacterial and biocompatibility properties. They can also be utilized as a self-cleaning coating material on glass and ceramic surfaces. Int J Nanomedicine. Zitao Zhou, Jino Son, Bryan Harper, Zheng Zhou, Stacey Harper, Influence of surface chemical properties on the toxicity of engineered zinc oxide nanoparticles to embryonic zebrafish, Beilstein Journal of Nanotechnology, 10.3762/bjnano.6.160, 6, (1568-1579), (2015). Several studies of ZnO NPs cytotoxicity have been conducted and they have shown that zinc oxide nanoparticles can affect many different animal cells , , , , , , , , , . Front Chem. Nano-Micro Letters, 7, 219-242 (2015). Zinc is a Block D, Period 4 element, while Oxygen is a Block P, Period 2 element. 2018 Apr;254:100. doi: 10.1016/j.cis.2018.04.006. A severe to slight damage was observed in liver tissue in all groups and tissue destruction was seen in kidney only in acute dose treated groups but no specific pathological effect in testis was observed (Fig. Microbial Fabrication of Zinc Oxide Nanoparticles and Evaluation of Their Antimicrobial and Photocatalytic Properties. Epub 2015 Nov 6. NIH USA.gov. With the wide application of ZnO-NPs, concern has been raised about its unintentional health and environmental impacts. J Nanosci Nanotechnol 2010, 10: 8617–8624. The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. Wang Y, Yuan L, Yao C, et al. 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